Suppressive effect of interleukin-4 neutralization differs for granulomas around Schistosoma mansoni eggs injected into mice compared with those around eggs laid in infected mice
نویسندگان
چکیده
منابع مشابه
The Role of Schistosoma Mansoni Eggs in Immune Protection against Plasmodium Berghei Infected Mice
The co-occurrence of malaria and schistosomiasis is common in tropical regions of the world. Malaria induces a strong Th1 response while schistosomiasis skews the response to a Th2. Several studies demonstrate a non consistent effect of schistosomiasis infection on progression of malaria. On one hand, schistosomiasis infections protect against cerebral malaria while on the other hand, they are ...
متن کاملPersistence of eggs and hepatic fibrosis after treatment of Schistosoma mansoni-infected mice.
In 1971 we estimated that Schistosoma mansoni eggs in the tissues of mice were destroyed with an approximate half-life of four weeks. Our present results of five experiments suggest that egg destruction is not as rapid, and no significant destruction of eggs was detected for up to 26 weeks after treatment. However, in these experiments, a mean of 60% of the eggs in intestinal tissues were found...
متن کاملConfocal Laser Scanning Microscopy for Detection of Schistosoma mansoni Eggs in the Gut of Mice
BACKGROUND The gold standard for diagnosing Schistosoma mansoni infections is the detection of eggs from stool or biopsy specimens. The viability of collected eggs can be tested by the miracidium hatching procedure. Direct detection methods are often limited in patients with light or early infections, whereas serological tests and PCR methods fail to differentiate between an inactive and persis...
متن کاملThe Schistosoma japonicum egg granuloma.
Although Schistosoma japonicum egg granulomas are generally considered to be similar to those of S. mansoni (which are largely immunologic reactions of the delayed hypersensitivity type) there are suggestions that the histopathology and perhaps the etiology of the lesions are different. In mice with light S. japonicum infections, at 5 weeks after infection (2 weeks after egg production began), ...
متن کاملMolecular characterization of an interleukin-4-inducing factor from Schistosoma mansoni eggs.
The eggs of the parasitic trematode Schistosoma mansoni are powerful inducers of a T helper type 2 (Th2) immune response and immunoglobulin E (IgE) production. S. mansoni egg extract (SmEA) stimulates human basophils to rapidly release large amounts of interleukin (IL)-4, the key promoter of a Th2 response. Here we show purification and sequence of the IL-4-inducing principle of S. mansoni eggs...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1995
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.63.7.2532-2536.1995